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Data on the role of POMC neurons in energy expenditure extend mostly to murine studies assessing action through MC4R

However, injections of 55 or 75 mg/kg/day of EGCG induced hepatotoxicity in mice, accompanied by inhibition of hepatic antioxidant enzymes and increased nuclear distribution of Nrf2 (231)

In terms of animal performance, RPM supplementation appears to have divergent responses depending on the developmental stage

Preclinical studies by Lv and colleagues have shown that GLP-1s can restore dopamine levels, inhibit dopaminergic loss, attenuate neuronal degeneration, and alleviate motor and non-motor features of PD