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Glutathione is a tripeptide (a group of three amino acids joined by peptide bonds) and includes the amino acids glutamine, glycine, and cysteine

They work by inhibiting tyrosinase activity, which reduces melanin production, and by shifting melanin production from darker eumelanin to lighter pheomelanin

Glucosamine induces resistance to insulin-like growth factor I (IGF-I) and insulin in Hep G2 cell cultures: biological significance of IGF-1/insulin hybrid receptors