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ROS promotes an increase in glycolysis in cellular respiration, shifting away from OXPHOS, which may contribute to tumorigenesis by triggering the Warburg effect [42]

Mutation Loci of the OAT2 ( SLC22A7 ) Gene Three quarters of OAT2 SNPs are found in men, and among the populations with these SNPs, the major allele frequencies of C329T , G571A , and G1520A were 0.94, 0.94, and 0.95, respectively (Xu et al., 2005)