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Parallel to the development of the glucagon-based co-agonists, investigations from an independent research group validated the concept, reporting anti-obesity properties for a chemically modified version of the gut hormone oxyntomodulin (OXM) [79]

Six RCTs reported liver function tests (AST, ALT, -GT) [13, 18, 3235], four RCTs reported lipid profile tests (HDL cholesterol, LDL cholesterol, total cholesterol, triglyceride) [13, 3234], six RCTs reported body indicators (BMI, weight, waist circumference) [17, 18, 3235], two RCTs reported inflammatory factors (hs-CRP) [16, 33], and two RCTs reported adverse events [32, 33]

A responsible doctor will screen for the following conditions before prescribing any GLP-1 injection or weight loss pills: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) History of pancreatitis or severe kidney disease Pregnancy or breastfeeding Type 1 diabetes requires a completely different treatment 7

But persistent foam that does not settle within a minute or two could indicate protein denaturation