For joint repair, consistent use over 3-6 months may be necessary to experience significant benefits
Summary: A hydroxocobalamin B12 injection typically maintains therapeutic levels for approximately 8 to 12 weeks in most patients, which is why maintenance injections are usually given every 2 to 3 months
You should contact your GP or NHS 111 if you experience: Persistent diarrhoea lasting more than 7 days in otherwise healthy adults Blood or mucus in stools , which may indicate inflammatory bowel disease or infection Severe abdominal pain or cramping that is worsening or different from previous digestive symptoms Unexplained weight loss alongside bowel changes Signs of allergic reaction , including rash, itching, swelling, or difficulty breathing (call 999 or go to A&E for severe reactions) Neurological symptoms such as numbness, tingling, balance problems, or memory difficulties, which may indicate B12 deficiency is not being adequately treated Seek help sooner if you have red flag symptoms, are pregnant, immunosuppressed, elderly, or have significant underlying health conditions
Individuals taking metformin alongside Mounjaro face higher B12 deficiency risk and may require more frequent monitoring
