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[14] A 2018 systematic review and meta-analysis of 12 randomized controlled trials found "supplementation significantly decreases depressive symptoms compared with placebo/no intervention, while offering a comparable effect with that of established antidepressant agents with fewer adverse effects." The review also indicates that "the effect of ALC in younger subjects was not more effective than placebo in improving these symptoms." indicating a need for more research explaining the age/effect relation

In primary cortical neurons subjected to OGD/R, Vitexin enhanced Nrf2 nuclear translocation by regulating Keap1, upregulated HO-1, GPX4, and SLC7A11, and reduced TFR1 expression (Guo and Shi, 2023)

Additionally, our observations that certain effects were more pronounced at specific doses of AcM (e.g., 300 mg/Kg) suggest that AcM supplementation may be most effective at optimized concentrations

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