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Treatment must be initiated and monitored by specialist weight management services, with specific BMI thresholds and comorbidity requirements

IV therapy provides: Immediate hydration at the cellular level Direct nutrient delivery bypassing compromised digestive absorption Targeted mineral replenishment for adrenal and nervous system support Antioxidant protection against stress-induced oxidative damage The Most Effective IV Formulations for Energy Recovery Realistic Expectations: Can IV Therapy Really Help

Neither guanosine nor adenosine significantly improved PB1 extrusion compared with aged groups (Supplementary Fig

The ESSENCE trial will continue to follow participants over a total duration of 240 weeks, with Part 2 designed to evaluate definitive clinical outcomes, including liver-related events, progression to cirrhosis, and all-cause and liver-related mortality