what is the mechanism of action of semaglutide Wegovy Dunedin Mechanism of action (MOA) of

Takeuchi O, Akira S

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Erhardt S, Lim CK, Linderholm KR, Janelidze S, Lindqvist D, Samuelsson M, et al

The cysteine content of the diet liver Cysteine transport Cystine transport Methionine transport Transsulfuration pathway Cysteine transport Na+ dependent High stereospecificity pH sensitive Not sensitive to adaptive regulation or insulin and glucagon stimulation Both inward and outward flows Influence by the extracellular levels of cysteine, and other system amino acids transporters Cystine transport Na+ independet Influence by pH change Entry of cystine accompanied by an exit of glutamate High intracellular glutamate concentration functions to stimulate the influx of cystine to maintain an adequate balance between cysteine and glutamate inside the cells Influence by : insulin, electrophilic agents and O2