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But it's suspected that along with killing cells directly, the virus may also trigger an immune reaction that fights melanoma by releasing antigens released from tumor cells, which are chemicals that trigger an immune response, and GM-CSF, a molecule that boosts the immune system [211, 212]

A similar phenomenon was also observed in estrogen-deficient mice (63)

Quick Take (TLDR) Mostly animal and in vitro data plus multiple very small uncontrolled human reports (knee pain case series n=16, interstitial cystitis pilot n=12, 2subject IV infusion) and no randomized controlled trials or published human pharmacokinetic profiles

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