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Due to narrow therapeutic windows resulting from limited MC3R/MC4R activity, suboptimal pharmacokinetics, and intolerable side effects, none were deemed efficacious in general obesity

The aim of this review is to summarize the most recent evidence on the activity and efficacy of exogenous antioxidants in patients with AD

Future research will likely focus on the mechanisms determining cell/tissue-selective expression and function of the androgen receptor in both normal and pathophysiological conditions and a more complete structural descriptions of the full-length receptor bound to different DNA response elements and co-regulatory proteins