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2APB: 2-aminoethoxydipenyl-borate APAP: acetaminophen DAMPs: damage-associated molecular patterns DMSO: dimethyl sulfoxide GSH: glutathione LDH: lactate dehydrogenase LPO: lipid peroxidation MPTP: mitochondrial membrane permeability transition pore NAC: N -acetylcysteine NK: natural killer NNT: nicotinamide nucleotide transhydrogenase P-JNK: phosphorylation of c-jun N-terminal kinase PUFAs: polyunsaturated fatty acids ROS: reactive oxygen species SEC: sinusoidal endothelial cell HJ: Conceptualization, Writingoriginal draft, Writingreview & editing

Mitochondrial superoxide anion can react with nitric oxide (NO) generating the reactive radical peroxynitrite (ONOO - ) and both superoxide anion and ONOO - formation in mitochondria are important events contributing to APAP-induced hepatotoxicity (Ramachandran and Jaeschke, 2017)

The packaging was professional, sealed properly, and the vials arrived in excellent condition

Retrieved from Qian, L., Wang, W., Zhou, Y., & Ma, J