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Subsequently, a stimulating effect of IGF-1 on collagen tissue in human tendon tissue is supported by in vivo studies, which have demonstrated that local administration of IGF-1 (1 mg) directly induced an elevation in collagen synthesis in human tendon tissue (Nielsen et al., 2024)

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This cellular priming provides the mechanistic foundation for FOXO4-DRI's selective targeting, enabling researchers to eliminate senescent cells without affecting healthy tissue function