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The much larger opportunity is preventing the downstream cascade: Type 2 diabetes, cardiovascular disease, fatty liver disease, kidney disease & perhaps even cognitive decline
Metformins generic availability provides significant cost advantages, particularly in resource-constrained healthcare systems where newer agents may be prohibitively expensive
4 Oxidative stress and ER stress: central pathways in vitiligo pathogenesis Vitiligo is associated with metabolic alterations, increased generation of ROS and increased susceptibility to mild exogenous stimuli in the epidermis
Free radicals, those unstable molecules that damage cells through oxidative stress, are major contributors to aging
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