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If total caloric intake has dropped below 1,200 calories daily (for women) or 1,500 calories (for men), you are likely in too aggressive a deficit

Misinterpretation of Benefits : Perceived benefits based on preclinical data may not translate to humans, which can lead to inappropriate use without proven outcomes

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doi:10.1038/sj.onc.1210796 Harris IS, Treloar AE, Inoue S et al (2015) Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression