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doi:10.1016/j.jinorgbio.2013.04.002

In more severe cases, oral medications may be necessary

The nuclei have uniform chromatin with a slightly clumped texture

The production of advanced glycation products (AGEs) increases with prolonged hyperglycemia, dyslipidemia, and oxidative stress, and the binding of AGEs to their receptors (RAGE) can further worsen the inflammatory state