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Overactivation of intracellular Nrf2 can not only promote the production of a series of downstream antioxidant enzymes but also increase the level of GSH, effectively inhibiting the progression of renal ischemia-reperfusion injury in the early stages (173)

In addition, seven candidate genes that may be involved in cold stress were selected based on the transcriptome analysis, and their promoters were analyzed to predict the factors that could regulate their expression

Tramadol abuse, with its risk of physical dependence, opiate use disorder and overdoses, is of concern worldwide and has led to it being a controlled drug in many countries

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