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These include nausea, vomiting, diarrhoea, and constipation, typically occurring during treatment initiation or dose escalation

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the threshold of 27 kg/m used in many anti-obesity trials reflects a pharmacotherapy eligibility criterion rather than the standard UK BMI classification

Data analysis Raw files were searched through Proteome Discoverer v.2.3 (Thermo Scientific) and spectra were queried against the human proteome (database downloaded from uniprot.org on 02/12/2019, containing 73662 sequences) using Sequest HT with a 1 % false discovery rate (FDR) applied