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DeFronzo RA, Inzucchi S, Abdul-Ghani M, Nissen SE (2019) Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes

445 participants with obesity and knee osteoarthritis, without diabetes, randomized 1:1:1 to 9mg, 12mg, or placebo over 68 weeks

These predispositions may help provide context for how your body might respond to different semaglutide doses, supporting more informed conversations with your provider about dosing strategy