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Circulating iron (Fe 3+ ) binds to transferrin (Tf), which then binds to specific transferrin receptor 1 (TFR1) and transfers to the cell

Central taxa across multiple levels (e.g., Sutterellaceae, Paludicola, Bacteroidales, Verrucomicrobiota) may play crucial roles in maintaining community structure and stability

Although we performed sensitivity analyses adjusting for diabetes, hypertension, race, and seropositivity, residual confounding from unmeasured factors may still be present. Additionally, EHR progress notes often lacked composite RA disease activity scores, such as Disease Activity Score in 28 joints and Clinical Disease Activity Index

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