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The desensitisation procedure should be started by the 1/1001/1000 solutions of the drug target or the 1/101/1000 solutions of positive intradermal test dose and in increasing doses by doubling with 3090min intervals until the therapeutic dose is achieved.5 Desensitisation must be carried out in a hospital setting by experienced personnel with adequate resuscitation equipment readily available

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Alternatively, 1000mcg SC/MC can be given every day for 2-7 days, followed by maintenance treatment

The GLP-1 receptor activation partially bypasses leptin pathways, maintaining appetite suppression even as leptin drops