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The histological characteristics of IC, including the thinning and erosion of the bladder epithelium, along with heightened infiltration by mast cells, suggest that the condition may stem from the compromised regenerative capacity of the bladders epithelial cells, coupled with anomalies in immune system functioning (Slobodov et al., 2004)

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In gastrointestinal research, BPC-157 is commonly studied through: gastric mucosal integrity intestinal barrier markers ulceration model scoring inflammatory mediator panels blood vessel response histology analysis NO pathway markers oxidative stress markers A 2020 study investigated stable gastric pentadecapeptide BPC-157 in clopidogrel-induced gastric injury models, looking at gastric protection and injury marker changes