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1517 At higher concentration produced by oxidative stress, 4HNE activates stress activated protein kinases (MAPKs, SAPKs), such as Jun-kinase, to trigger oxidative stress defenses through the AP2 (FOS/JUN heterodimer), NRF2, NFkB, and p53

People who prefer this approach over synthetic hormone replacement often gravitate toward sermorelin and similar hormone-balancing peptides

Hormonal Balance and Aging Gracefully Other peptides are also effective at helping balance hormonal levels in aging women, making peptide therapy an ideal treatment for perimenopausal and postmenopausal women seeking ways to tame the aging process

Curr Hypertens Rep 2002