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It is important to note that all scientifically verified effects described below are based on preclinical research, including in vivo rodent models and in vitro cellular systems

Clean the injection site, choose a spot with enough flesh, and aim for subcutaneous tissue without hitting any blood vessels

Accordingly, in some embodiments, cyclodextrins are included to increase the solubility of the therapeutic agents, or auris-acceptable otic agents, within the formulations or compositions described herein