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*Wegovy has recently become licensed for weight loss in the UK

Unmanaged diabetes, defined as an A1C greater than 8%, leads to both macrovascular and microvascular damage affecting the heart and kidneys, which ultimately leads to increased morbidity and mortality

This makes it particularly harmful because it: delivers fatty acids directly to the liver worsens liver insulin resistance drives inflammation drives up sdLDL that cannot easily be removed by LDL receptors (and is principle cause of coronary artery disease) accelerates cardiovascular disease Visceral fat becomes both a marker of metabolic overload and a driver of further damage

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