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Moving to the ability of metformin to reduce the metastatic potential, it was demonstrated that the drug not only reduced the migration of MTC cancer cells (Klubo-Gwiezdzinska et al., 2012), but also modified the expression of several markers of the epithelial-tomesenchimal-transition (EMT) (Han et al., 2015)

Diabetes Obes Metab 25:19321941 Fadini GP, Frison V, Rigato M, Morieri ML, Simioni N, Tadiotto F, DAmbrosio M, Paccagnella A, Lapolla A, Avogaro A (2020) Trend 20102018 in the clinical use of GLP-1 receptor agonists for the treatment of type 2 diabetes in routine clinical practice: an observational study from Northeast Italy

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