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Aged mice in the study showed signs of endothelial dysfunction, increased vascular stiffness, and impaired coronary microcirculation, which are hallmarks of HFpEF [17]

Several approaches have been described, including the use of natural albumin-binding proteins such as antibody fragments binding to serum albumin 22,23,24 , albumin-binding peptides 25 , the streptococcal protein G-derived albumin-binding domain 26,27 , and serum albumin-binding DARPin 28