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116,117 Additionally, Smurf1 stabilizes sterol regulatory element-binding protein-1c (SREBP-1c), a key transcription factor in lipid metabolism, by preventing its ubiquitination and degradation, while BTRC promotes the proteasomal degradation of adipose triglyceride lipase

It also highlights individual sensitivity and dose-dependency as modifying factors influencing the intensity of the effects

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15 Figure 1: Example of Normal Sleep Architecture Opportunities for Sleep Optimization: Falling Asleep & Staying Asleep For many people reading this overview, opportunities to leverage sleep optimization to enhance performance will center around one of two themes, or sometimes bothmaking it easier to fall asleep or stay asleep