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Semaglutide is the only GLP-1 monoagonist with completed cardiovascular outcome data in both diabetic and non-diabetic populations

But the real mechanism behind why the body chooses where to burn fat next is more surprising than most people expect

Patient selection considerations include: Adults with BMI 30 kg/m or 27 kg/m with weight-related comorbidities [1] [7] Contraindications must be carefully reviewed, including personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis, gallbladder disease, severe gastrointestinal disease, or renal impairment requires caution Not recommended during pregnancy or lactation Clinicians should counsel patients that while inflammatory marker improvements have been observed in research settings, Zepbound is prescribed for weight management, not inflammation treatment

Higher doses often lead to greater weight reduction