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*Correspondence: Lili Zhou, [email protected] These authors have contributed equally to this work This article was submitted to Renal Pharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

For patients with less severe cognitive problems, specifically mild cognitive impairment or early-stage Alzheimer's disease, the clinical trial evidence is slightly more positive but also less reliable [11].

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