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Another potential pathway that enhances FXR activity involves the release of the growth factor fibroblast growth factor (FGF) 19 from the intestine upon bile acid binding to FXR, 66 which has shown beneficial effects on MASH in animal models, although results are conflicting

You highlight a key issue: lean mass is too often used as a proxy for muscle, leaving the functional implications unclear

The decision to switch medications should always involve your healthcare team, but the evidence increasingly supports GLP-1 monotherapy or GLP-1 plus metformin as safer, more effective alternatives to older drug combinations

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