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By synthesizing current research advancements, the present review aims to provide new perspectives on the common pathological pathways underlying these diseases and to establish a theoretical foundation to guide the development of effective clinical interventions

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Additional biomarker candidates include plasma MDA and BALF 4-HNE, which reflect oxidative damage and correlate with disease severity (159), and genetic markers such as FADS1 polymorphisms that influence membrane lipid unsaturation and peroxidation susceptibility

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