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These steps provide a concrete framework for translating mechanistic insightssuch as CYP3A4/OATP1B1 involvementinto clinical practice (Table 6)

For patients with a hungry brain, switching to dual agonists such as tirzepatide (commercially known as Mounjaro), which targets two digestive hormones, GLP-1 and glucose-dependent insulinotropic peptide (GIP) may be useful

Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]

Discontinue if irritation occurs, and consult a dermatologist if needed