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(2015) reported results from a Phase 3 clinical trial of afamelanotide in erythropoietic protoporphyria, demonstrating increased time to phototoxicity symptoms and supporting regulatory approval [2]

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Over 50% of CM cases report activating mutation of the BRAF gene (79), while merely 16% of MMs experience the same alteration ( BRAF is distinct from NRAS in MM in that the locus undergoes amplification in 13% of cases ( BRAF gene are missense mutations and they most frequently occur at codon 600, the activating loop, where amino acids change from valine to glutamic acid (V600E) (93)

Waitlisting and liver transplantation for MetALD in the United States: an analysis of the UNOS national registry