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Due to overwhelming demand, both semaglutide and tirzepatide have experienced periodic shortages of certain dosage strengths

Results vary by dose

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However, bioavailability could not be reliably estimated since the chosen dose level for intravenous administration was too low for the terminal part of the concentration-time curve to be apparent, and the plasma semaglutide exposure levels in this single-dose trial were generally insufficient for a robust estimation of bioavailability