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NeuroImage: Clinical 8, 117125

In addition to cytoskeletal proteins, enzymes involved in sperm metabolism and energy production are also affected by oxidative stress (75, 76)

Stress management reduces cortisol levels accelerating collagen breakdown and promoting inflammation undermining peptide skin improvements - regular exercise supporting cortisol regulation and circulation, meditation or mindfulness practices reducing stress response, adequate social connection and support networks, and professional help for chronic stress or anxiety creating physiological effects beyond lifestyle modifications

Most patients see initial improvements within 3-4 weeks , with continued progress over months