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Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes

Li J, Wu W, Kong X, Yang X, Li K, Jiang Z, et al

Adding a CYP51 inhibitor slows BBR metabolism, preventing the production of demethylated metabolites, including thalifendine and berberrubine (Zhang et al., 2021a)

or BMI 27 kg/m with at least one indicator of increased cardiovascular risk (e.g., coronary heart disease, hypertension, dyslipidemia, diabetes, elevated waist circumference), or another obesity-related medical condition (e.g., sleep apnea)