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The rationale for dual-receptor agonists for GLP-1 and GIP In healthy volunteers, infusions of GLP-1 and GIP had additive effects on the stimulation of insulin secretion (42)

These compounded GLP-1 drugs may include custom microdose formulations, and some are marketed for off-label uses like longevity or cognitive support, though experts warn that their safety and effectiveness remain unproven

We propose that shared pathwaysparticularly altered sex hormone levelsmay explain this protective association [9]

Real World Impact: Current Use and Outcomes These medications are no longer niche, they're influencing population level trends: Rapid Growth in Use In the U.S., reported use of GLP-1 weight loss drugs has more than doubled in the past year, from about 5.8% of adults in early 2024 to over 12% in 2025 Women tend to use these medications at higher rates than men, with 15.2% vs