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Targeting the incretin/glucagon system with triagonists An even more advanced step towards the generation of an effective anti-obesity pharmacotherapy is the report of a single peptide capable of simultaneously activating the receptors for glucagon, GLP-1, and GIP by using a highly effective, balanced triagonist structure [25]

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(2011), since transactivation during glutamate oxidation can provide the needed aspartate (Figure 3B), but GDH-mediated -ketoglutarate cannot

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