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201,202 Micronized progesterone (Prometrium) is a bioidentical form of progesterone, while dydrogesterone (Duphaston), medroxyprogesterone (Provera), norethindrone (Aygestin), and levonorgestrel (used in the combination product Climara) are among the synthetic progestins used in combination hormone therapy after menopause

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It has been reported that silencing of PTEN cooperates with activated AKT to promote metastasis of melanoma (102, 103, 106, 107), but MM does not show a weaker performance in metastasis than CM in the clinic possibly because there are other gene alterations in the PI3K pathway promoting invasiveness of tumor (108)