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For individuals with BMI above 30 or BMI above 27 with comorbidities, FDA-approved GLP-1 receptor agonists (semaglutide, tirzepatide) have far stronger evidence and produce dramatically greater weight loss

Furigo IC, Melo HM, Lyra ESNM, Ramos-Lobo AM, Teixeira PDS, Buonfiglio DC, Wasinski F, Lima ER, Higuti E, Peroni CN, Bartolini P, Soares CRJ, Metzger M, de Felice FG, Donato J

10.1136/jnnp-2023-331131 71 MalcolmR.LiaoJ.MichelM.CochranK.PyeW.YeagerD.et al (2002)

In an email, Jong-Hwei Su Pang, a professor at Chang Gung Universitys Graduate Institute of Clinical Medical Sciences, wrote that the peptide might be produced by stomach microbes, as its amino acid sequence doesnt appear in the human genome