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Magnetic resonance spectroscopy (MRS) allows the insight into their pathophysiology through exploration of a range of biochemicals putatively relevant to aetiological processes, in particular mitochondrial dysfunction and energy metabolism

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The two factors particularly involved in differentiation of the lactotroph, somatotroph, and thyrotroph lineages are Prop-1 (Prophet of Pit-1) and Pit-1, also known as GHF-1 and Pou1f1

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