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Exenatide activated eNOS and NO production in endothelial cells, induced dose-dependent vasorelaxation, and mitigated high-glucose or lipid-induced endothelial dysfunction in arterioles ex vivo, effects which were reduced by AMPK (AMP-activated protein kinase) inhibition [86]

GLP-1 therapy can significantly slow or prevent steroid-related weight gain, though results vary by individual

Another limitation of this study is the lack of experiments exploring the molecular dynamics of NTZ in the improvement of MTX-mediated liver toxicity in more details in a cell culture model

Eur J Clin Invest (2015) 45:123442.10.1111/eci.12542 165 BestermanHSMallinsonCNModiglianiRChristofidesNDPeraAPontiVet alGut hormones in inflammatory bowel disease