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The expression of the E3 ubiquitin ligase TRIM3 is significantly reduced in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), which are predominant subtypes of non-small cell lung cancer (NSCLC), but overexpression of TRIM3 can increase ROS levels and LPO in cancer cells, promoting ferroptosis[77]

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Figure 2 To date, little is known about specific predictive factors for treatment response, especially for pharmacotherapy (40)

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