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13 Saxagliptin: Saxagliptin (Onglyza) was approved by the FDA in July 2009

The data supporting its use is based on in vitro cell culture studies and animal model research demonstrating its superior local potency

apparel industry, reported in March 2026 that 80 percent of GLP-1 users anticipated wardrobe changes associated with their impending weight loss, and that 55 percent of active GLP-1 users had already made such clothing purchases

In another observational study of patients aged 40 years with T2D, body mass index 25 kg/m 2 , and pre-existing ischemic heart disease, tirzepatide was associated with a lower rate of the primary composite outcome of all-cause mortality, myocardial infarction, and ischemic stroke (HR 0.60, 95% CI 0.430.84), as well as reductions in all individual components of the composite outcome [29]