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Acknowledgements We thank the research team at the Royal Canin Pet Health and Nutrition Centre (Lewisburg, OH) for care of the study cats, sample collection and analysis

By using 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR), a near IR fluorescent and hydrophobic carbocyanine, as a fluorescence tracking agent, whole body imaging demonstrated that COXP micelles delivered DiR to mouse brains about 20 times higher than DiR administered alone [52]