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Metabolically, inadequate vitamin B12 status is associated with the accumulation of MMA, a specific functional marker of vitamin B12 deficiency ( -oxidation, and potentially exacerbating lipid accumulation in the liver and peripheral tissues, thereby aggravating IR ( , and IL-6 ( Faecalibacterium , decreasing Bacteroides populations, and promoting the production of SCFAs, particularly butyrate ( The interaction between vitamin B12 and folic acid represents one of their core biological relationships