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Two major causes of black stools include: Medical conditions Food or Medications The medical conditions that may cause black, tarry stools include the following: Peptic ulcer Esophageal dysfunction Colon polyps Abnormal blood vessels Mallory-Weiss tear Ischemic bowel disease Gastritis Trauma or foreign body Cancer Black stool and peptic ulcer Black stools are an indication of peptic ulcer

Drug Metab Dispos 23(3):406414 Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W (1986) Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity

Additionally, glutathione disulfide (GSSG) plays a crucial role in managing oxidative stress in chronic illnesses by maintaining the balance between reduced and oxidized glutathione

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