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Barrier dysfunction is documented and accepted in conditions such as celiac disease and Crohn's disease , and the phenomenon has been studied since the 1970s

Mar-Alexandre J, Barcel-Molina M, Belmonte-Lpez E, Garca-Oms J, Estells A, Braza-Bols A, et al

Moreover, KO mice for liver IGF-1 gene developed muscle insulin resistance (it is important to mention that skeletal muscle myocytes express high number of IGF-1R), showing an increase in insulin concentrations and a substantial decrease in the insulin-induced autophosphorylation of the insulin receptor and IRS in skeletal muscle (being normal in liver and white adipose tissue)

Pain levels (1-10 scale)