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254,255 High-fat diet-fed mice treated with exendin-4 (a hormone found in the saliva of the Gila monster which is synthetically modified to produce exenatide for T2D treatment) had decreased mRNA levels of the pro-inflammatory cytokines tumour necrosis factor-alpha, monocyte chemoattractant protein 1 and signal transducer and activator of transcription 3
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Research indicates that autophagy activation may enhance drug resistance in tumor cells during chemotherapy, as autophagy can clear drug-induced cellular damage, thereby protecting tumor cell survival ( 3.4 Epigenetic modifications In recent years, research has demonstrated that epigenetic modifications play a crucial role in the drug resistance of HGSOC, including changes in DNA methylation, histone modifications, and non-coding RNA expression