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Research indicates that individuals with BP-I remain symptomatic for nearly half of their illness course, with depressive symptoms being the most frequent and persistent, significantly outweighing manic/hypomanic and mixed episodes (Nierenberg et al., 2023)

The inborn redox nature of alkaline salts, such as Na 2 CO 3 , also accelerates toxicity by generating ROS, such as superoxide anions (O 2 ), hydrogen peroxide (H 2 O 2 ), and hydroxyl radicals (OH ) 9,10

Endogenous importance does not validate every product Water, glucose and insulin are also endogenous or physiologically essential, but their medical effects depend on dose, route, formulation, diagnosis and product quality